PDRN, or polydeoxyribonucleotide, is a DNA-derived ingredient usually taken from salmon or trout. Clinics inject it, while serums apply it to the skin's surface. Those are very different uses, so results from injected PDRN do not automatically apply to a serum.
Where does PDRN come from?
PDRN is made from purified DNA fragments, mainly taken from salmon or trout. Researchers are also testing microbial and plant sources, though that work is at an early stage.
How is a PDRN serum different from an injection?
The main difference is where the ingredient goes. An injection places it in the skin, while a serum stays on the surface and has to get past the skin barrier.
| Clinic injection | Cosmetic serum | |
|---|---|---|
| Who applies it | Trained practitioner | You, at home |
| Where it goes | Into the skin | Onto the skin |
| Main research | Aesthetic medicine | Limited |
| Purpose | Clinical procedure | Cosmetic care |
What does the research say about topical PDRN?
There is much less evidence for serums than for injections. One 2026 paper says topical use is limited by poor stability and delivery, which is why researchers are testing new carriers.
So treat a PDRN serum as a hydrating cosmetic, not as a home version of a clinic treatment.
What should you look for on the label?
Look for PDRN or Sodium DNA, and see where it sits in the list. In our PDRN Peptide Serum, Sodium DNA is ingredient 9 of 27, alongside niacinamide, panthenol and four peptides.
Common questions
Is PDRN really made from salmon?
Most PDRN comes from salmon or trout, but plant and microbial versions are being developed. Check with the brand if the source matters to you, especially if you avoid fish-derived ingredients or have an allergy.
Is sodium DNA the same as PDRN?
Sodium DNA is the INCI name you will often see on a cosmetic label for DNA-derived ingredients. PDRN describes a particular purified fragment range, so ask the brand how its ingredient is specified.